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are many silk fibres with compatible biomedical properties which are of the
following types of silk fibre:

Silk worm silk (Bombyx mori):

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Silk obtained
from cocoon of Bombyx mori
are commonly used for biomedical and textile production. Sericulture is
commonly known for breeding of silks for commercial scale production of raw
silk.   Cocoon of Bombyx mori consist
of two major fibrous proteins. Silk from silkworm is used for decades together
for various biomedical applications and various clinical repair needs like
sutures due to is greater tensile strength and good mechanical properties.
Biocompatibility is a major concern with silkworm silk due to contamination of
various residual protein fibres like sericin. Sericin protein in silkworm have
water soluble glycoprotein and consist of 25-30% of cocoon weight overall, due
to 18 amino acid, polar groups and hydrophilic protein. Various recent studies
proved and suggested that core silk protein fibre (fibroin) exhibits very good
mechanical and biocompatible properties. Silkworm silk are commonly used for
designing scaffolds and culture medium in tissue engineering. It is
demonstrated many antioxidant properties both invitro and in vivo, which proves
that sericin
has good immunological properties that safe for many tissue applications which
include vehicle for drug delivery, wound healing, immunological response,
antitumor effect, cryopreservation and various metabolic effects in human
system. Physiochemical properties like functional properties of sericin protein
fibre depends upon the extraction method and process used for sericin isolation
and lineage of the silkworm which can increase the biocompatibility of the
fibre for biomedical applications.

Spider Silk (Nephila

Spider silk
generally consist of 7 diverse silk glands, each has a different purpose of
production and have different mechanical properties and biodegradability.
Commercial production of spider silk is hampered due to nature of spidroins
due to very less
production of silk and hence it is not extensively used in textile industry
neither much in biomedical applications. Dragline silk from Nephila
clavipes which is commonly cloned for natural and
synthetic genes encoding recombinants to limit the use of native organism.
Dragline silk consist of polyalanine
and glycine–glycine-R region where R is often referred to tyrosine, glutamine or leucine.
As the Spider Silk are commonly known for good absorbance energy due
extraordinary strength and extendibility. Various strategies of productions are
demonstrated and conducted to increase the repetitive production of Spider
silk. Spider Silk is commonly known in biomedical applications due to its
ability to heal wound as well as to stop excessive haemorrhage. Several
redissolution methods and procedures are carried to demonstrate the application
of spider silk in restoring and repairing the functions of damaged tissue like

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