On Friday, January 19th, a graduating senior
Kennedy Goldsborough did a presentation on mitochondrial protein homeostasis in
peripheral axons. Kennedy Goldsborough is a biochemistry major. Kennedy
conducted all of her research at Harvard Medical School and at the Boston
Children’s Hospital. The purpose of her research was to screen new
mitochondrial protein synthesis and to select if there will be an expansion or
decline in mitochondrial rates. An axon is a long, slim projection of a nerve
cell, or neuron, that normally leads electrical driving forces known as
activity possibilities, far from the nerve cell body. The purpose of the axon
is to transmit data to various neurons, muscles, and organs.
In order to
conduct this experiment, Kennedy used TFB2M cells as her mitochondria sample. TFB2M
(Transcription Factor B2, Mitochondrial) is a protein coding gene. This
transcription aspect triggers transcription of human mitochondrial DNA. Before
directing the research, she needed to advance haloblock with the goal that the
perfect measure of halotag was included. The following thing done was the TFB2M
was added to the neurons of the protein. By doing this, she could distinguish
the distinctive proteins from one another. Kennedy’s research was unable to be
finished but rather she expressed what her further plans were. These designs
included evaluating the mitochondria and contrasting the rates of the synthesis
in the soma versus in distilled cells. The soma or cell body is the portions of
a neuron or other brain cell compose, containing the cell nucleus.
“Soma” originates from the Greek word, signifying “body”.
research was very intriguing to me because it could definitely be used in the
medical field when especially dealing with diseases that kill axons. Although
her research was not completed, it was still an interesting topic. One of the
things that I would critique with her presentation was the way she answered
some of the questions. It sounded as if she wasn’t really sure of the answer.
She was unable to answer a few of the questions. I look forward to listening to
the next presentation on Friday, January 26th.