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In 2017 Angela Babetski Holton et alldesign a specific microfloudics  trappingdevices for real time monitoring of cancer cell1.            In2017 Mario Rothbauer et. al have studied recent advanced technology for making 2D or 3D of cancer cell theirinteraction  and they also developedadvanced micro devices to intrigrate multiple organs for human body2.In 2017 Uday K. Veeramallu   explore that the MetaCellTM separators have the potential to serve asvery effective adjunctive aids for the selection and monitoring of ovariancancer patients for treatment with targeted therapies3.In 2017 Paridhi Puri,Vijay Kumar, M.

Ananthasubramanian et al Design, simulation and fabrication of MEMS baseddielectrophoretic separator for bio-particles. Also found thesimulation results for the optimization of dielectrophoretic device ispresented and discussed in detail. Simulation results for cell separation iscarried out in a circular channel driven by AC field and the process model withfabricated device. Compared with the previously reported dielectrophoreticseparation devices, this structure achieves continuous separation and alsominimizes dead volumes4.In 2017, Muhamad R. Buyong; Farhad Larki; YuzuruTakamura; Burhanuddin Yeop Majlispresents explore the fabrication, characterization,and simulation of microelectrode arrays system with tapered profile having analuminum surface for dielectrophoresis (DEP)-based manipulation of particles.

The proposed structure demonstrates more effective electric field gradientcompared with its counterpart with untapered profile. Therefore, according tothe asymmetric distribution of the electric field in the active region ofmicroelectrode, it produces more effective particle manipulation5.In 2016 Bahareh Haddadi, Morteza Fathipour perform the numerical analysis of 3D micro floudic device model of cell separator having different densities byusing Standing Surface Acoustic Waves6 . In 2016, Aissa Foughalia, S.

Noorjannah Ibrahim explore separation efficiency of the microfluidic device in continuous flowbased on results of a 3D model simulation conducted in COMSOL Multiphysics. Theproposed device enables label-free cell separation and thus, it can be a usefulmicrofluidic component for lab-on-a-chip system and integrated biological andbiomedical applications 7.In 2016Lee et al explores current DACS capabilities worldwide, and it also looks atrecent developments intended to overcome particular limitations.

First, thebasic theories are reviewed. Then, representative DACSes based on DEP trapping,traveling wave DEP systems, DEP field-flow fractionation and DEP barriers areintroduced, and the strong and weak points of each DACS are discussed. Finally,for the purposes of commercialization, prerequisites regarding throughput,efficiency and recovery rates are discussed in detail through comparisons withcommercial cell sorters (e.g. fluorescent activated and magnetic activated cellsorters)8.In 2016, A Heidariperform the Comparative Study on Simultaneous Determination and Separation ofAdsorbed Cadmium Oxide (CdO) Nanoparticles on DNA/RNA of Human Cancer CellsUsing Biospectroscopic Techniques and Dielectrophoresis (DEP) Method 9.In 2016, Mehdi Sahmani , MousaVatanmakanian , Mehdi et al established that the  several characteristics of a microchip canunder shadow its overall functions which are include: the physics of the chipand its dimensions; material used in its synthesis; types of pumps, channelsand valves; chip manufacturing technology; the type, quantity, quality andsample processing, reliability, standardization, precision and the sensitivityof chip for sampling, analysis and final recording of the results.

In the nearfuture each of these features might be a topic for different challenges and investigations.Conclusively, further development of ingeniously designed micro-systems,identification of proper materials with a high bio-compatibility for chipmanufacturing, discovering novel biomarkers, optimizing the integration ofvarious processes on a single platform, and using highly efficientbio-detectors in the structure of microchips can help to largely enhance theearly diagnosis of human cancers. In fact, in the current scientific communitywhich with the advent of modern technology and advanced equipments is rapidlydeveloping, chip-based cancer monitoring like the other large research projectshas been turned out to an extensive field of study and has been able to obviatemany concerns regarding the human cancers and the related challenges. It isvaluable to note that this trend is progressively going through forward whichcan bring promising achievements for health-care system10.In 2015, Peng Lia , Zhangming Maoa ,Zhangli Peng et al validated the capability of this device by successfullyseparating low concentrations (?100cells/mL) of a variety of cancer cells from cell culture lines from WBCs with arecovery rate better than 83%. We then demonstrated the isolation of CTCs inblood samples obtained from patients with breast cancer. Our acoustic-basedseparation method thus offers the potential to serve as an invaluablesupplemental tool in cancer research, diagnostics, drug efficacy assessment,and therapeutics owing to its excellent biocompatibility, simple design, andlabel-free automated operation while offering the capability to isolate rareCTCs in a viable state11.In 2015 , LongPang,  Shaofei Shen,  Chao Ma et al design a micro floudicdevices for cancer cell separation based on size 12.

In  2015 ,Liu, Yeonju Lee , Joon hee Jang et al developed one microfloudics devices usedfor  Microfluidic cytometric  analysis of cancer cell transportability andinvasiveness 13.In 2015, Ryan M.Williams and Letha J  describes theSelection of MREs using differential cell SELEX represents a powerful method ofdifferentiating between cell types. This process requires no prior knowledge ofcell surface molecule expression and takes advantage of differential expressionprofiles.

Peptide and antibody fragment libraries, the host on which thelibrary is displayed, and the selection method each have advantages andsituations in which they are useful. As more MREs are being developed, it iscertain that their uses and clinical investigation will continue to expand14.In 2015, A. C. S.

Talari, C. A. Evans et al showed thatRaman spectra of the cell lines have revealed that basic differences in theconcentration of biochemical compounds such as lipids, nucleic acids andprotein Raman peaks were found to differ in intensity, and principal componentanalysis (PCA) was able to identify variations that lead to accurate andreliable separation of the three cell lines. Linear discriminant analysis (LDA)model of three cell lines was predicted with 100% sensitivity and 91%specificity. We have shown that a combination of Raman spectroscopy andchemometrics are capable of differentiation between breast cancer cell lines.These variations may be useful in identifying new spectral markers todifferentiate different subtypes of breast cancer although this needsconfirmation in a larger panel of cell lines as well as clinical material 15.

In 2014 Nedhi at el explores the currentapplication of MEMS in cell reorganization and their DNA analysis 16.In 2014 , Su S, Liu Q, Chen J et al  showed that mesenchymal-like breast cancer cells activate macrophages to aTAM-like phenotype by GM-CSF. Reciprocally, CCL18 from TAMs induces cancer cellEMT, forming a positive feedback loop, in coculture systems and humanized mice.Inhibition of GM-CSF or CCL18 breaks this loop and reduces cancer metastasis 17.In 2014 EnsiehFarahani Hirak K. Patra Jaganmohan R.

Jangamreddy et al drawcomparison between reprogramming and carcinogenesis, as well as between stemcells (SCs) and cancer stem cells (CSCs), focusing on changing garniture ofadhesion molecules. They also  elaborateon the role of adhesion molecules in the regulation of (cancer) SCs division(symmetric or asymmetric), and in evolving interactions between CSCs and extracellularmatrix 18.In  2014, Adeeti V.

Ullal, Vanessa Peterson  et  al. describes that Cancer cell profiling by bar coding allowsmultiplexed protein analysis in fine needle aspirates 19.In 2014 Shailender Singh Kanwar,Christopher James Dunlay et al. design and implementation of on chip microfloudic devices for isolation, quantification and characterization ofcirculating exosomes for cancer cell 20.

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