Inparragraph 2nd Dual inhibition PI3K/mTOR shows anticancer activity in MLLrearranged leukaemias (Reference missing). Sentence should be Recent reportshave shown that Simultaneous inhibition of PI3K/mTOR has shows anticanceractivity in MLL rearranged leukaemias10 In paragraph sixthGlycogen Synthase kinase3 supports MLL leukemia proliferation andmaintainance.GSK3 inhibition induces G1 arrest and cell death in MLL transformedcells.
GSK3-? inhibition increased survival in mouse model of MLL associatedleukaemic. Sentence should be Glycogen Synthase kinase3 has shown to support MLL leukemia proliferation18.GSK3 inhibitionhas shown to induce G1 growth arrest andcell death in MLL transformed cells18. GSK3-?inhibition has shown to increase survival in mouse model of MLL associatedleukaemic 18.In paragraph seventhActivation of SIRT1 and inhibition of DOTIL can be an effective therapy formixed lineage leukemia.SIRT1 mediates silencing of the MLL-AF9 leukemic programupon DOT1L inactivation by H3K9 deacetylation (19).
Sentence should beActivation of SIRT1 and at same time inhibition of DOTIL has been shown be an effective therapy for mixed lineageleukemia20.SIRT1activation mediated silencing of theMLL-AF9 leukemia has been shown to be enhanced by simultaneous DOT1L inhibition20 In paragraph ninthTET1 is significantly up-regulated in MLL-rearranged leukemia, leading to aglobal increase of 5- hydroxymethylcytosine level (23) TET1 is a fusion partnerof MLL (reference missing) Sentenceshould be TET1 has shown to be highly expressed in MLL-rearranged leukemiacells with leads to drastic increase of 5-hydroxymethylcytosine levels (23) In paragraphthirteen These compounds inhibit the growth of leukemia cells in vitro as wellas prolonged the survival MLL leukemic mice(reference missing).Sentenceshould be These compounds showed to inhibit the growth of leukemia cells in vitroas well as prolonged the survival of MLLleukemic mice34.