“A sane man often reasons from sound premises; an insane man commonly reasons as well, but the premises are unsound” (O’Malley). The tragedy of Macbeth centers on the fact that insanity is the result of a guilty conscience. After killing King Duncan, Macbeth says, “How is’t with me, when every noise appals me? / What hands are here! Ha, they pluck out mine eyes. / Will all great Neptune’s ocean wash this blood / Clean from my hand? No, this my hand will rather / The multitudinous seas incarnadine, / Making the green one red. ” (II.ii.27-29) He feels outrageous blame for carrying out the wrongdoing of killing him. The murder begins with him wanting to end up a King ruins Macbeth’s life making him to feel blamed. The word that Macbeth used to say easily, Amen, suddenly turned into a word that is difficult to say. Macbeth is confident that he will never have God’s safety again since he presented a real murder. He winds up not being able to say the word Amen or God. The statement, “Macbeth murders rest” deduces that Macbeth will agonizedly experience the ill effects of the sentimental blame. The statement demonstrates the harassment Macbeth encounters after running King Duncan and Banquo.”How is’t with me, when every noise appals me? / What hands are here! Ha, they pluck out mine eyes. / Will all great Neptune’s ocean wash this blood / Clean from my hand? No, this my hand will rather / The multitudinous seas incarnadine, / Making the green one red. “(II.ii.58-63). Neptune is a Roman God of the ocean.In the line, “Will all extraordinary Neptune’s sea wash this blood,” this demonstrates that even the God of the Sea would not be able to wash the blood off of his hands. Now, Macbeth’s blame achieves its peak, where Macbeth now doesn’t feel regretful. Additionally, The shading green in the quote above symbolizes Macbeth being jealous of anyone who has control, since the shading green speaks to desire.”I am in blood/Stepp’d in so far, that, should I wade no more,/Returning were as tedious as go o’er.” (III.iv.142-144). This statement is revealed right after Macbeth sees the ghost of Banquo who dishonors Macbeth showing guiltiness to Macbeth, pushing him further into blame. Macbeth recognizes that he had changed a lot because of the influence of Lady Macbeth. He has changed himself into a killer. He can hardly imagine how he has done such a wrongdoing just to end up plainly a ruler. Apparently, he weeps what he has done and needs to go back in time, however he is now stuck in regret. This statement shows Macbeth’s plan to go back in time when he had done nothing that would dissent with his soul, yet he as of now “ventured in up until now” that he can’t escape any longer.Macbeth’s horror looks at the way madness is the after-effect of a feeling of remorse. Macbeth feels outrageous blame for killing the King which starts his fall into insanity. Once Macbeth murdered Banquo, he began seeing his ghost resulting Macbeth to reach the crest of insanity.